AustralieFrV1, Main, Exploration, bibRecord, 002F29

Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides

Identifieur interne : 002F29 ( Main/Exploration ); précédent : 002F28; suivant : 002F30

Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides

Auteurs : Joost P. Schanstra [France] ; Petra Zürbig [Allemagne] ; Alaa Alkhalaf [Pays-Bas] ; Angel Argiles [France] ; Stephan J. L. Bakker [Pays-Bas] ; Joachim Beige [Allemagne] ; Henk J. G. Bilo [Pays-Bas] ; Christos Chatzikyrkou [Allemagne] ; Mohammed Dakna [Allemagne] ; Jesse Dawson [Royaume-Uni] ; Christian Delles [Royaume-Uni] ; Hermann Haller [Allemagne] ; Marion Haubitz [Allemagne] ; Holger Husi [Royaume-Uni] ; Joachim Jankowski [Allemagne] ; George Jerums [Australie] ; Nanne Kleefstra [Pays-Bas] ; Tatiana Kuznetsova ; David M. Maahs [États-Unis] ; Jan Menne [Allemagne] ; William Mullen [Royaume-Uni] ; Alberto Ortiz [Espagne] ; Frederik Persson [Danemark] ; Peter Rossing [Danemark] ; Piero Ruggenenti [Italie] ; Ivan Rychlik [République tchèque] ; Andreas L. Serra [Suisse] ; Justyna Siwy [Allemagne] ; Janet Snell-Bergeon [États-Unis] ; Goce Spasovski [Macédoine (pays)] ; Jan A. Staessen ; Antonia Vlahou [Grèce, Royaume-Uni] ; Harald Mischak ; Raymond Vanholder [Belgique]

Source :

Journal of the American Society of Nephrology : JASN [ 1046-6673 ] ; 2015.

RBID : PMC:4520165

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Humains, Insuffisance rénale chronique (urine), Marqueurs biologiques (urine), Mâle, Peptides (urine), Sujet âgé, Taux de filtration glomérulaire, Études de cohortes, Évolution de la maladie.
MESH :
- urine : Adulte, Adulte d'âge moyen, Femelle, Humains, Insuffisance rénale chronique, Marqueurs biologiques, Mâle, Peptides, Sujet âgé, Taux de filtration glomérulaire, Études de cohortes, Évolution de la maladie.

English descriptors

KwdEn :
- Adult, Aged, Biomarkers (urine), Cohort Studies, Disease Progression, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Peptides (urine), Renal Insufficiency, Chronic (urine).
MESH :
- chemical , urine : Biomarkers, Peptides.
- urine : Renal Insufficiency, Chronic.
- Adult, Aged, Cohort Studies, Disease Progression, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged.

Abstract

Progressive CKD is generally detected at a late stage by a sustained decline in eGFR and/or the presence of significant albuminuria. With the aim of early and improved risk stratification of patients with CKD, we studied urinary peptides in a large cross-sectional multicenter cohort of 1990 individuals, including 522 with follow-up data, using proteome analysis. We validated that a previously established multipeptide urinary biomarker classifier performed significantly better in detecting and predicting progression of CKD than the current clinical standard, urinary albumin. The classifier was also more sensitive for identifying patients with rapidly progressing CKD. Compared with the combination of baseline eGFR and albuminuria (area under the curve [AUC]=0.758), the addition of the multipeptide biomarker classifier significantly improved CKD risk prediction (AUC=0.831) as assessed by the net reclassification index (0.303±−0.065; P<0.001) and integrated discrimination improvement (0.058±0.014; P<0.001). Correlation of individual urinary peptides with CKD stage and progression showed that the peptides that associated with CKD, irrespective of CKD stage or CKD progression, were either fragments of the major circulating proteins, suggesting failure of the glomerular filtration barrier sieving properties, or different collagen fragments, suggesting accumulation of intrarenal extracellular matrix. Furthermore, protein fragments associated with progression of CKD originated mostly from proteins related to inflammation and tissue repair. Results of this study suggest that urinary proteome analysis might significantly improve the current state of the art of CKD detection and outcome prediction and that identification of the urinary peptides allows insight into various ongoing pathophysiologic processes in CKD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520165

DOI: 10.1681/ASN.2014050423
PubMed: 25589610
PubMed Central: 4520165

Affiliations:

Le document en format XML

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<author><name sortKey="Kleefstra, Nanne" sort="Kleefstra, Nanne" uniqKey="Kleefstra N" first="Nanne" last="Kleefstra">Nanne Kleefstra</name>
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<author><name sortKey="Kuznetsova, Tatiana" sort="Kuznetsova, Tatiana" uniqKey="Kuznetsova T" first="Tatiana" last="Kuznetsova">Tatiana Kuznetsova</name>
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</author>
<author><name sortKey="Maahs, David M" sort="Maahs, David M" uniqKey="Maahs D" first="David M." last="Maahs">David M. Maahs</name>
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<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora</wicri:cityArea>
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<author><name sortKey="Menne, Jan" sort="Menne, Jan" uniqKey="Menne J" first="Jan" last="Menne">Jan Menne</name>
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<author><name sortKey="Mullen, William" sort="Mullen, William" uniqKey="Mullen W" first="William" last="Mullen">William Mullen</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Ortiz, Alberto" sort="Ortiz, Alberto" uniqKey="Ortiz A" first="Alberto" last="Ortiz">Alberto Ortiz</name>
<affiliation wicri:level="3"><nlm:aff id="aff18">School of Medicine, Jimenez Diaz Foundation Institute for Health Research, Autonomous University of Madrid, Madrid, Spain;</nlm:aff>
<country xml:lang="fr">Espagne</country>
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</affiliation>
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<author><name sortKey="Persson, Frederik" sort="Persson, Frederik" uniqKey="Persson F" first="Frederik" last="Persson">Frederik Persson</name>
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<country xml:lang="fr">Danemark</country>
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</affiliation>
</author>
<author><name sortKey="Rossing, Peter" sort="Rossing, Peter" uniqKey="Rossing P" first="Peter" last="Rossing">Peter Rossing</name>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff20">Faculty of Health, University of Aarhus, Aarhus, Denmark;</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Faculty of Health, University of Aarhus, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff21">Faculty of Health, University of Copenhagen, Copenhagen, Denmark;</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Faculty of Health, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
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<author><name sortKey="Ruggenenti, Piero" sort="Ruggenenti, Piero" uniqKey="Ruggenenti P" first="Piero" last="Ruggenenti">Piero Ruggenenti</name>
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<author><name sortKey="Rychlik, Ivan" sort="Rychlik, Ivan" uniqKey="Rychlik I" first="Ivan" last="Rychlik">Ivan Rychlik</name>
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<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague</wicri:regionArea>
<placeName><settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Serra, Andreas L" sort="Serra, Andreas L" uniqKey="Serra A" first="Andreas L." last="Serra">Andreas L. Serra</name>
<affiliation wicri:level="4"><nlm:aff id="aff24">Division of Nephrology, University Hospital, and Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Switzerland;</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Nephrology, University Hospital, and Epidemiology, Biostatistics and Prevention Institute, University of Zurich</wicri:regionArea>
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<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
<orgName type="university">Université de Zurich</orgName>
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</author>
<author><name sortKey="Siwy, Justyna" sort="Siwy, Justyna" uniqKey="Siwy J" first="Justyna" last="Siwy">Justyna Siwy</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>mosaiques diagnostics GmbH, Hanover</wicri:regionArea>
<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff13">Department of Internal Medicine IV, Charity Medical University of Berlin, Berlin, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine IV, Charity Medical University of Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Snell Bergeon, Janet" sort="Snell Bergeon, Janet" uniqKey="Snell Bergeon J" first="Janet" last="Snell-Bergeon">Janet Snell-Bergeon</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Spasovski, Goce" sort="Spasovski, Goce" uniqKey="Spasovski G" first="Goce" last="Spasovski">Goce Spasovski</name>
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<author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A." last="Staessen">Jan A. Staessen</name>
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</affiliation>
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</placeName>
</affiliation>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Biomedical and Healthcare Sciences, Plymouth University, Plymouth</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Mischak, Harald" sort="Mischak, Harald" uniqKey="Mischak H" first="Harald" last="Mischak">Harald Mischak</name>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vanholder, Raymond" sort="Vanholder, Raymond" uniqKey="Vanholder R" first="Raymond" last="Vanholder">Raymond Vanholder</name>
<affiliation wicri:level="1"><nlm:aff id="aff28">Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides</title>
<author><name sortKey="Schanstra, Joost P" sort="Schanstra, Joost P" uniqKey="Schanstra J" first="Joost P." last="Schanstra">Joost P. Schanstra</name>
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<wicri:regionArea>Institute of Cardiovascular and Metabolic Disease, French Institute of Health and Medical Research U1048, Toulouse</wicri:regionArea>
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<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2">Paul Sabatier University (Toulouse III), Toulouse, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paul Sabatier University (Toulouse III), Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
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<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zurbig, Petra" sort="Zurbig, Petra" uniqKey="Zurbig P" first="Petra" last="Zürbig">Petra Zürbig</name>
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<country xml:lang="fr">Allemagne</country>
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<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alkhalaf, Alaa" sort="Alkhalaf, Alaa" uniqKey="Alkhalaf A" first="Alaa" last="Alkhalaf">Alaa Alkhalaf</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University Medical Center Groningen and University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Argiles, Angel" sort="Argiles, Angel" uniqKey="Argiles A" first="Angel" last="Argiles">Angel Argiles</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>RD Néphrologie, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bakker, Stephan J L" sort="Bakker, Stephan J L" uniqKey="Bakker S" first="Stephan J. L." last="Bakker">Stephan J. L. Bakker</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">University Medical Center Groningen and University of Groningen, Groningen, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University Medical Center Groningen and University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beige, Joachim" sort="Beige, Joachim" uniqKey="Beige J" first="Joachim" last="Beige">Joachim Beige</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>KfH Renal Unit, Department Nephrology, Leipzig and Martin-Luther-University, Halle/Wittenberg</wicri:regionArea>
<wicri:noRegion>Halle/Wittenberg</wicri:noRegion>
<wicri:noRegion>Halle/Wittenberg</wicri:noRegion>
<wicri:noRegion>Halle/Wittenberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bilo, Henk J G" sort="Bilo, Henk J G" uniqKey="Bilo H" first="Henk J. G." last="Bilo">Henk J. G. Bilo</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">University Medical Center Groningen and University of Groningen, Groningen, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University Medical Center Groningen and University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7">Diabetes Centre, Isala Clinics, Zwolle, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Diabetes Centre, Isala Clinics, Zwolle</wicri:regionArea>
<wicri:noRegion>Zwolle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chatzikyrkou, Christos" sort="Chatzikyrkou, Christos" uniqKey="Chatzikyrkou C" first="Christos" last="Chatzikyrkou">Christos Chatzikyrkou</name>
<affiliation wicri:level="3"><nlm:aff id="aff8">Department of Nephrology and Hypertension, University Hospital of Magdeburg, Magdeburg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nephrology and Hypertension, University Hospital of Magdeburg, Magdeburg</wicri:regionArea>
<placeName><region type="land" nuts="2">Saxe-Anhalt</region>
<settlement type="city">Magdebourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dakna, Mohammed" sort="Dakna, Mohammed" uniqKey="Dakna M" first="Mohammed" last="Dakna">Mohammed Dakna</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">mosaiques diagnostics GmbH, Hanover, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>mosaiques diagnostics GmbH, Hanover</wicri:regionArea>
<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dawson, Jesse" sort="Dawson, Jesse" uniqKey="Dawson J" first="Jesse" last="Dawson">Jesse Dawson</name>
<affiliation wicri:level="4"><nlm:aff id="aff9">BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delles, Christian" sort="Delles, Christian" uniqKey="Delles C" first="Christian" last="Delles">Christian Delles</name>
<affiliation wicri:level="4"><nlm:aff id="aff9">BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haller, Hermann" sort="Haller, Hermann" uniqKey="Haller H" first="Hermann" last="Haller">Hermann Haller</name>
<affiliation wicri:level="1"><nlm:aff id="aff10">Department of Nephrology and Hypertension, Medical School of Hanover, Hanover, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nephrology and Hypertension, Medical School of Hanover, Hanover</wicri:regionArea>
<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haubitz, Marion" sort="Haubitz, Marion" uniqKey="Haubitz M" first="Marion" last="Haubitz">Marion Haubitz</name>
<affiliation wicri:level="1"><nlm:aff id="aff11">Department of Nephrology, Klinikum Fulda gAG, Fulda, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nephrology, Klinikum Fulda gAG, Fulda</wicri:regionArea>
<wicri:noRegion>Fulda</wicri:noRegion>
<wicri:noRegion>Fulda</wicri:noRegion>
<wicri:noRegion>Fulda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Husi, Holger" sort="Husi, Holger" uniqKey="Husi H" first="Holger" last="Husi">Holger Husi</name>
<affiliation wicri:level="4"><nlm:aff id="aff9">BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jankowski, Joachim" sort="Jankowski, Joachim" uniqKey="Jankowski J" first="Joachim" last="Jankowski">Joachim Jankowski</name>
<affiliation wicri:level="3"><nlm:aff id="aff12">Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Aix-la-Chapelle</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff13">Department of Internal Medicine IV, Charity Medical University of Berlin, Berlin, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine IV, Charity Medical University of Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jerums, George" sort="Jerums, George" uniqKey="Jerums G" first="George" last="Jerums">George Jerums</name>
<affiliation wicri:level="4"><nlm:aff id="aff14">Austin Health, University of Melbourne, Heidelberg, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Austin Health, University of Melbourne, Heidelberg</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kleefstra, Nanne" sort="Kleefstra, Nanne" uniqKey="Kleefstra N" first="Nanne" last="Kleefstra">Nanne Kleefstra</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University Medical Center Groningen and University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7">Diabetes Centre, Isala Clinics, Zwolle, The Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Diabetes Centre, Isala Clinics, Zwolle</wicri:regionArea>
<wicri:noRegion>Zwolle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kuznetsova, Tatiana" sort="Kuznetsova, Tatiana" uniqKey="Kuznetsova T" first="Tatiana" last="Kuznetsova">Tatiana Kuznetsova</name>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maahs, David M" sort="Maahs, David M" uniqKey="Maahs D" first="David M." last="Maahs">David M. Maahs</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Menne, Jan" sort="Menne, Jan" uniqKey="Menne J" first="Jan" last="Menne">Jan Menne</name>
<affiliation wicri:level="1"><nlm:aff id="aff10">Department of Nephrology and Hypertension, Medical School of Hanover, Hanover, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nephrology and Hypertension, Medical School of Hanover, Hanover</wicri:regionArea>
<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mullen, William" sort="Mullen, William" uniqKey="Mullen W" first="William" last="Mullen">William Mullen</name>
<affiliation wicri:level="4"><nlm:aff id="aff9">BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ortiz, Alberto" sort="Ortiz, Alberto" uniqKey="Ortiz A" first="Alberto" last="Ortiz">Alberto Ortiz</name>
<affiliation wicri:level="3"><nlm:aff id="aff18">School of Medicine, Jimenez Diaz Foundation Institute for Health Research, Autonomous University of Madrid, Madrid, Spain;</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>School of Medicine, Jimenez Diaz Foundation Institute for Health Research, Autonomous University of Madrid, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Persson, Frederik" sort="Persson, Frederik" uniqKey="Persson F" first="Frederik" last="Persson">Frederik Persson</name>
<affiliation wicri:level="1"><nlm:aff id="aff19">Steno Diabetes Center, Gentofte, Denmark;</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Steno Diabetes Center, Gentofte</wicri:regionArea>
<wicri:noRegion>Gentofte</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rossing, Peter" sort="Rossing, Peter" uniqKey="Rossing P" first="Peter" last="Rossing">Peter Rossing</name>
<affiliation wicri:level="1"><nlm:aff id="aff19">Steno Diabetes Center, Gentofte, Denmark;</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Steno Diabetes Center, Gentofte</wicri:regionArea>
<wicri:noRegion>Gentofte</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff20">Faculty of Health, University of Aarhus, Aarhus, Denmark;</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Faculty of Health, University of Aarhus, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff21">Faculty of Health, University of Copenhagen, Copenhagen, Denmark;</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Faculty of Health, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruggenenti, Piero" sort="Ruggenenti, Piero" uniqKey="Ruggenenti P" first="Piero" last="Ruggenenti">Piero Ruggenenti</name>
<affiliation wicri:level="1"><nlm:aff id="aff22">Mario Negri Institute of Pharmacology Research, Bergamo, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Mario Negri Institute of Pharmacology Research, Bergamo</wicri:regionArea>
<wicri:noRegion>Bergamo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rychlik, Ivan" sort="Rychlik, Ivan" uniqKey="Rychlik I" first="Ivan" last="Rychlik">Ivan Rychlik</name>
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<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague</wicri:regionArea>
<placeName><settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Serra, Andreas L" sort="Serra, Andreas L" uniqKey="Serra A" first="Andreas L." last="Serra">Andreas L. Serra</name>
<affiliation wicri:level="4"><nlm:aff id="aff24">Division of Nephrology, University Hospital, and Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Switzerland;</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Nephrology, University Hospital, and Epidemiology, Biostatistics and Prevention Institute, University of Zurich</wicri:regionArea>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
<orgName type="university">Université de Zurich</orgName>
</affiliation>
</author>
<author><name sortKey="Siwy, Justyna" sort="Siwy, Justyna" uniqKey="Siwy J" first="Justyna" last="Siwy">Justyna Siwy</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">mosaiques diagnostics GmbH, Hanover, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>mosaiques diagnostics GmbH, Hanover</wicri:regionArea>
<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
<wicri:noRegion>Hanover</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff13">Department of Internal Medicine IV, Charity Medical University of Berlin, Berlin, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine IV, Charity Medical University of Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Snell Bergeon, Janet" sort="Snell Bergeon, Janet" uniqKey="Snell Bergeon J" first="Janet" last="Snell-Bergeon">Janet Snell-Bergeon</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Spasovski, Goce" sort="Spasovski, Goce" uniqKey="Spasovski G" first="Goce" last="Spasovski">Goce Spasovski</name>
<affiliation wicri:level="1"><nlm:aff id="aff25">University Department of Nephrology, Medical Faculty, University of Skopje, Skopje, Macedonia;</nlm:aff>
<country xml:lang="fr">Macédoine (pays)</country>
<wicri:regionArea>University Department of Nephrology, Medical Faculty, University of Skopje, Skopje</wicri:regionArea>
<wicri:noRegion>Skopje</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A." last="Staessen">Jan A. Staessen</name>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vlahou, Antonia" sort="Vlahou, Antonia" uniqKey="Vlahou A" first="Antonia" last="Vlahou">Antonia Vlahou</name>
<affiliation wicri:level="3"><nlm:aff id="aff26">Division of Biotechnology, Biomedical Research Foundation, Academy of Athens, Athens, Greece;</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Division of Biotechnology, Biomedical Research Foundation, Academy of Athens, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff27">School of Biomedical and Healthcare Sciences, Plymouth University, Plymouth, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Biomedical and Healthcare Sciences, Plymouth University, Plymouth</wicri:regionArea>
<wicri:noRegion>Plymouth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mischak, Harald" sort="Mischak, Harald" uniqKey="Mischak H" first="Harald" last="Mischak">Harald Mischak</name>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vanholder, Raymond" sort="Vanholder, Raymond" uniqKey="Vanholder R" first="Raymond" last="Vanholder">Raymond Vanholder</name>
<affiliation wicri:level="1"><nlm:aff id="aff28">Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of the American Society of Nephrology : JASN</title>
<idno type="ISSN">1046-6673</idno>
<idno type="eISSN">1533-3450</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Biomarkers (urine)</term>
<term>Cohort Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Glomerular Filtration Rate</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Peptides (urine)</term>
<term>Renal Insufficiency, Chronic (urine)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Insuffisance rénale chronique (urine)</term>
<term>Marqueurs biologiques (urine)</term>
<term>Mâle</term>
<term>Peptides (urine)</term>
<term>Sujet âgé</term>
<term>Taux de filtration glomérulaire</term>
<term>Études de cohortes</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Biomarkers</term>
<term>Peptides</term>
</keywords>
<keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Renal Insufficiency, Chronic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cohort Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Glomerular Filtration Rate</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Insuffisance rénale chronique</term>
<term>Marqueurs biologiques</term>
<term>Mâle</term>
<term>Peptides</term>
<term>Sujet âgé</term>
<term>Taux de filtration glomérulaire</term>
<term>Études de cohortes</term>
<term>Évolution de la maladie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Progressive CKD is generally detected at a late stage by a sustained decline in eGFR and/or the presence of significant albuminuria. With the aim of early and improved risk stratification of patients with CKD, we studied urinary peptides in a large cross-sectional multicenter cohort of 1990 individuals, including 522 with follow-up data, using proteome analysis. We validated that a previously established multipeptide urinary biomarker classifier performed significantly better in detecting and predicting progression of CKD than the current clinical standard, urinary albumin. The classifier was also more sensitive for identifying patients with rapidly progressing CKD. Compared with the combination of baseline eGFR and albuminuria (area under the curve [AUC]=0.758), the addition of the multipeptide biomarker classifier significantly improved CKD risk prediction (AUC=0.831) as assessed by the net reclassification index (0.303±−0.065; <italic>P</italic>
<0.001) and integrated discrimination improvement (0.058±0.014; <italic>P</italic>
<0.001). Correlation of individual urinary peptides with CKD stage and progression showed that the peptides that associated with CKD, irrespective of CKD stage or CKD progression, were either fragments of the major circulating proteins, suggesting failure of the glomerular filtration barrier sieving properties, or different collagen fragments, suggesting accumulation of intrarenal extracellular matrix. Furthermore, protein fragments associated with progression of CKD originated mostly from proteins related to inflammation and tissue repair. Results of this study suggest that urinary proteome analysis might significantly improve the current state of the art of CKD detection and outcome prediction and that identification of the urinary peptides allows insight into various ongoing pathophysiologic processes in CKD.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Belgique</li>
<li>Danemark</li>
<li>Espagne</li>
<li>France</li>
<li>Grèce</li>
<li>Italie</li>
<li>Macédoine (pays)</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>République tchèque</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Attique (région)</li>
<li>Berlin</li>
<li>Bohême centrale</li>
<li>Canton de Zurich</li>
<li>Colorado</li>
<li>Communauté de Madrid</li>
<li>District de Cologne</li>
<li>Groningue (province)</li>
<li>Hovedstaden</li>
<li>Languedoc-Roussillon</li>
<li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Saxe-Anhalt</li>
<li>Victoria (État)</li>
<li>Écosse</li>
</region>
<settlement><li>Aix-la-Chapelle</li>
<li>Athènes</li>
<li>Berlin</li>
<li>Copenhague</li>
<li>Glasgow</li>
<li>Groningue</li>
<li>Madrid</li>
<li>Magdebourg</li>
<li>Melbourne</li>
<li>Montpellier</li>
<li>Prague</li>
<li>Toulouse</li>
<li>Zurich</li>
</settlement>
<orgName><li>Université de Glasgow</li>
<li>Université de Melbourne</li>
<li>Université de Zurich</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Kuznetsova, Tatiana" sort="Kuznetsova, Tatiana" uniqKey="Kuznetsova T" first="Tatiana" last="Kuznetsova">Tatiana Kuznetsova</name>
<name sortKey="Mischak, Harald" sort="Mischak, Harald" uniqKey="Mischak H" first="Harald" last="Mischak">Harald Mischak</name>
<name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A." last="Staessen">Jan A. Staessen</name>
</noCountry>
<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Schanstra, Joost P" sort="Schanstra, Joost P" uniqKey="Schanstra J" first="Joost P." last="Schanstra">Joost P. Schanstra</name>
</region>
<name sortKey="Argiles, Angel" sort="Argiles, Angel" uniqKey="Argiles A" first="Angel" last="Argiles">Angel Argiles</name>
<name sortKey="Schanstra, Joost P" sort="Schanstra, Joost P" uniqKey="Schanstra J" first="Joost P." last="Schanstra">Joost P. Schanstra</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Zurbig, Petra" sort="Zurbig, Petra" uniqKey="Zurbig P" first="Petra" last="Zürbig">Petra Zürbig</name>
</noRegion>
<name sortKey="Beige, Joachim" sort="Beige, Joachim" uniqKey="Beige J" first="Joachim" last="Beige">Joachim Beige</name>
<name sortKey="Chatzikyrkou, Christos" sort="Chatzikyrkou, Christos" uniqKey="Chatzikyrkou C" first="Christos" last="Chatzikyrkou">Christos Chatzikyrkou</name>
<name sortKey="Dakna, Mohammed" sort="Dakna, Mohammed" uniqKey="Dakna M" first="Mohammed" last="Dakna">Mohammed Dakna</name>
<name sortKey="Haller, Hermann" sort="Haller, Hermann" uniqKey="Haller H" first="Hermann" last="Haller">Hermann Haller</name>
<name sortKey="Haubitz, Marion" sort="Haubitz, Marion" uniqKey="Haubitz M" first="Marion" last="Haubitz">Marion Haubitz</name>
<name sortKey="Jankowski, Joachim" sort="Jankowski, Joachim" uniqKey="Jankowski J" first="Joachim" last="Jankowski">Joachim Jankowski</name>
<name sortKey="Jankowski, Joachim" sort="Jankowski, Joachim" uniqKey="Jankowski J" first="Joachim" last="Jankowski">Joachim Jankowski</name>
<name sortKey="Menne, Jan" sort="Menne, Jan" uniqKey="Menne J" first="Jan" last="Menne">Jan Menne</name>
<name sortKey="Siwy, Justyna" sort="Siwy, Justyna" uniqKey="Siwy J" first="Justyna" last="Siwy">Justyna Siwy</name>
<name sortKey="Siwy, Justyna" sort="Siwy, Justyna" uniqKey="Siwy J" first="Justyna" last="Siwy">Justyna Siwy</name>
</country>
<country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Alkhalaf, Alaa" sort="Alkhalaf, Alaa" uniqKey="Alkhalaf A" first="Alaa" last="Alkhalaf">Alaa Alkhalaf</name>
</region>
<name sortKey="Bakker, Stephan J L" sort="Bakker, Stephan J L" uniqKey="Bakker S" first="Stephan J. L." last="Bakker">Stephan J. L. Bakker</name>
<name sortKey="Bilo, Henk J G" sort="Bilo, Henk J G" uniqKey="Bilo H" first="Henk J. G." last="Bilo">Henk J. G. Bilo</name>
<name sortKey="Bilo, Henk J G" sort="Bilo, Henk J G" uniqKey="Bilo H" first="Henk J. G." last="Bilo">Henk J. G. Bilo</name>
<name sortKey="Kleefstra, Nanne" sort="Kleefstra, Nanne" uniqKey="Kleefstra N" first="Nanne" last="Kleefstra">Nanne Kleefstra</name>
<name sortKey="Kleefstra, Nanne" sort="Kleefstra, Nanne" uniqKey="Kleefstra N" first="Nanne" last="Kleefstra">Nanne Kleefstra</name>
</country>
<country name="Royaume-Uni"><region name="Écosse"><name sortKey="Dawson, Jesse" sort="Dawson, Jesse" uniqKey="Dawson J" first="Jesse" last="Dawson">Jesse Dawson</name>
</region>
<name sortKey="Delles, Christian" sort="Delles, Christian" uniqKey="Delles C" first="Christian" last="Delles">Christian Delles</name>
<name sortKey="Husi, Holger" sort="Husi, Holger" uniqKey="Husi H" first="Holger" last="Husi">Holger Husi</name>
<name sortKey="Mullen, William" sort="Mullen, William" uniqKey="Mullen W" first="William" last="Mullen">William Mullen</name>
<name sortKey="Vlahou, Antonia" sort="Vlahou, Antonia" uniqKey="Vlahou A" first="Antonia" last="Vlahou">Antonia Vlahou</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Jerums, George" sort="Jerums, George" uniqKey="Jerums G" first="George" last="Jerums">George Jerums</name>
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</country>
<country name="États-Unis"><region name="Colorado"><name sortKey="Maahs, David M" sort="Maahs, David M" uniqKey="Maahs D" first="David M." last="Maahs">David M. Maahs</name>
</region>
<name sortKey="Snell Bergeon, Janet" sort="Snell Bergeon, Janet" uniqKey="Snell Bergeon J" first="Janet" last="Snell-Bergeon">Janet Snell-Bergeon</name>
</country>
<country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ortiz, Alberto" sort="Ortiz, Alberto" uniqKey="Ortiz A" first="Alberto" last="Ortiz">Alberto Ortiz</name>
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<country name="Danemark"><noRegion><name sortKey="Persson, Frederik" sort="Persson, Frederik" uniqKey="Persson F" first="Frederik" last="Persson">Frederik Persson</name>
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<name sortKey="Rossing, Peter" sort="Rossing, Peter" uniqKey="Rossing P" first="Peter" last="Rossing">Peter Rossing</name>
<name sortKey="Rossing, Peter" sort="Rossing, Peter" uniqKey="Rossing P" first="Peter" last="Rossing">Peter Rossing</name>
<name sortKey="Rossing, Peter" sort="Rossing, Peter" uniqKey="Rossing P" first="Peter" last="Rossing">Peter Rossing</name>
</country>
<country name="Italie"><noRegion><name sortKey="Ruggenenti, Piero" sort="Ruggenenti, Piero" uniqKey="Ruggenenti P" first="Piero" last="Ruggenenti">Piero Ruggenenti</name>
</noRegion>
</country>
<country name="République tchèque"><region name="Bohême centrale"><name sortKey="Rychlik, Ivan" sort="Rychlik, Ivan" uniqKey="Rychlik I" first="Ivan" last="Rychlik">Ivan Rychlik</name>
</region>
</country>
<country name="Suisse"><region name="Canton de Zurich"><name sortKey="Serra, Andreas L" sort="Serra, Andreas L" uniqKey="Serra A" first="Andreas L." last="Serra">Andreas L. Serra</name>
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<country name="Macédoine (pays)"><noRegion><name sortKey="Spasovski, Goce" sort="Spasovski, Goce" uniqKey="Spasovski G" first="Goce" last="Spasovski">Goce Spasovski</name>
</noRegion>
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<country name="Grèce"><region name="Attique (région)"><name sortKey="Vlahou, Antonia" sort="Vlahou, Antonia" uniqKey="Vlahou A" first="Antonia" last="Vlahou">Antonia Vlahou</name>
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<country name="Belgique"><noRegion><name sortKey="Vanholder, Raymond" sort="Vanholder, Raymond" uniqKey="Vanholder R" first="Raymond" last="Vanholder">Raymond Vanholder</name>
</noRegion>
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</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides

Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides

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